Code:
@ARTICLE{Ameyaw2001,
author = {Ameyaw, M.M. and Regateiro, F. and Li, T. and Liu, X. and Tariq,
M. and Mobarek, A. and Thornton, N. and Folayan, G.O. and Githang'a,
J. and Indalo, A. and Ofori-Adjei, D. and Price-Evans, D.A. and McLeod,
H.L.},
title = {MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26
is significantly influenced by ethnicity},
journal = {Pharmacogenetics},
year = {2001},
volume = {11},
pages = {217--221},
number = {3},
month = apr,
abstract = {P-glycoprotein (PGP), the product of the multidrug resistance gene
(MDR1), acts as an energy-dependent efflux pump that exports its
substrates out of the cell. PGP expression is an important factor
regulating absorption of a wide variety of medications. It has also
been associated with intrinsic and acquired cross resistance to a
number of structurally unrelated anticancer drugs. A single nucleotide
polymorphism (SNP) in exon 26 of the MDR1 gene, C3435T, was recently
correlated with PGP protein levels and substrate uptake. Individuals
homozygous for the T allele have more than four-fold lower PGP expression
compared with CC individuals. As overexpression of PGP has been associated
with altered drug absorption, therapy-resistant malignancies, and
lower concentrations of HIV-1 protease inhibitors, this SNP may provide
a useful approach to individualize therapy. To facilitate clinical
application throughout the world, 1280 subjects from 10 different
ethnic groups were evaluated for this SNP using the polymerase chain
reaction-restriction fragment length polymorphism assay and the genotype
and allele frequency for each group were ascertained. Marked differences
in genotype and allele frequency were apparent between the African
populations and the Caucasian/Asian populations (P < 0.0001). The
Ghanaian, Kenyan, African American and Sudanese populations studied
had frequencies of 83%, 83%, 84% and 73%, respectively, for the C
allele. The British Caucasian, Portuguese, South-west Asian, Chinese,
Filipino and Saudi populations had lower frequencies of the C allele
compared to the African group (48%, 43%, 34%, 53%, 59%, and 55%,
respectively). The high frequency of the C allele in the African
group implies overexpression of PGP and may have important therapeutic
and prognostic implications for use of PGP dependent drugs in individuals
of African origin},
address = {University of Aberdeen, Department of Medicine and Therapeutics,
Institute of Medical Sciences, Foresterhill, Aberdeen, UK},
comment = {DA - 20010507 IS - 0960-314X (Print) IS - 0960-314X (Linking) LA -
eng PT - Journal Article PT - Research Support, Non-U.S. Gov't RN
- 0 (P-Glycoprotein) SB - IM},
keywords = {Adolescent, Aged, Alleles, DNA Mutational Analysis, Ethnic Groups,
Exons, Female, Gene Frequency, Genes,Mdr, genetics, Genotype, Heart
Rate, Humans, Male, Middle Aged, Mutation, P-Glycoprotein, Pharmacogenetics,
physiology, Point Mutation, Polymerase Chain Reaction, Polymorphism,Restriction
Fragment Length, Polymorphism,Single Nucleotide, Research},
owner = {Martin},
refid = {112},
timestamp = {2012.10.29},
url = {PM:11337937}
}
Den month in{} hab ich schon probiert, bekomme aber den selben Fehler: Runaway Argument.
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